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Abstract #1957

Synaptic Amyloid Beta Affects Neural Conductivity But May Not Lead to Pre-synaptic Axonal Degeneration

Shu-Wei Sun 1 , Chen-Fang Chung 2 , Christopher Nishioka 3 , Hsiao-Fang Liang 2 , and Wei-Xing Shi 2

1 Loma Linda University, Loma Linda, CA, United States, 2 Loma Linda University, CA, United States, 3 University of California, Riverside, CA, United States

Synaptic deficits and brain atrophy are two major hallmarks in Alzheimers disease. Synaptic deficits usually occur early in contrast to the neuronal loss which usually occurs late. Thus, it is speculated that the early synaptic deficits may facilitate the later neuronal loss. A-beta was injected in the lateral geniculate nucleus, which affected the synapses but not the soma of RGCs. A-beta injected in axonal terminals may impair synapses to adversely affect the neural signal conduction. However, the injured synapses may not lead to a retrograded axonal degeneration to cause a neuronal loss.

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