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Abstract #1978

Convergent and Divergent Dynamic Functional Connectivity Patterns between Patients with Refractory and Nonrefractory Major Depressive Disorders

Bochao Cheng 1 , Lin Yuan 2 , Xuhong Liao 3 , Su Lui 1 , Xiaoqi Huang 1 , Yong He 2 , and Qiyong Gong 1

1 HMRRC.Radiology Department, West China hospital of Sichuan University, Chengdu, Sichuan, China, 2 State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China, 3 Center for Cognition and Brain Disorders, Hangzhou Normal University, Zhejiang, China

We chose the left subgenual ACC as the seed region and explored the differed dynamic functional connectivity (D-FC) patterns in refractory and nonrefractory MDD in resting-state fMRI with the VPR combined with Kalman filtering approach. The results suggested that D-FC method can reveal the dysfunction brain network which is widely verified by the traditional static FC of MDD. And the cortical-limbic circuit, especially the prefrontal/temporalClimbic circuit, is the most stable varying important dysfunction brain network in MDD. The frontal part of left OFC, which shows reversed activity in MDD subtypes, may provide new insight into evaluate the treatment.

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