Abstract #1978
Convergent and Divergent Dynamic Functional Connectivity Patterns between Patients with Refractory and Nonrefractory Major Depressive Disorders
Bochao Cheng 1 , Lin Yuan 2 , Xuhong Liao 3 , Su Lui 1 , Xiaoqi Huang 1 , Yong He 2 , and Qiyong Gong 1
1
HMRRC.Radiology Department, West China
hospital of Sichuan University, Chengdu, Sichuan, China,
2
State
Key Laboratory of Cognitive Neuroscience and Learning,
Beijing Normal University, Beijing, China,
3
Center
for Cognition and Brain Disorders, Hangzhou Normal
University, Zhejiang, China
We chose the left subgenual ACC as the seed region and
explored the differed dynamic functional connectivity
(D-FC) patterns in refractory and nonrefractory MDD in
resting-state fMRI with the VPR combined with Kalman
filtering approach. The results suggested that D-FC
method can reveal the dysfunction brain network which is
widely verified by the traditional static FC of MDD. And
the cortical-limbic circuit, especially the prefrontal/temporalClimbic
circuit, is the most stable varying important
dysfunction brain network in MDD. The frontal part of
left OFC, which shows reversed activity in MDD subtypes,
may provide new insight into evaluate the treatment.
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