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Abstract #1998

Cortical thickness correlates with symptoms in adolescents newly diagnosed with Obsessive-Compulsive Disorder

Oscar Gustafsson 1,2 , Maria Ljungberg 1,2 , Arvid Carlsson 3 , Maria L Carlsson 3 , Eva Forssell-Aronsson 1,2 , Tord Ivarsson 4 , Lars Jnsson 5 , Karin Melin 4 , and Gran Starck 1,2

1 Division of Medical Physics and Medical Engineering, Sahlgrenska University Hospital, Gteborg, Sweden, 2 Department of Radiation Physics, Gteborg University, Gteborg, Sweden, 3 Institute of Neuroscience and Physiology, Gteborg University, Gteborg, Sweden, 4 Department of Child & Adolescent Psychiatry, Gteborg University, Gteborg, Sweden, 5 Department of Radiology, Sahlgrenska University Hospital, Gteborg, Sweden

A morphometric analysis of treatment-nave adolescents newly diagnosed with obsessive-compulsive disorder (OCD), utilizing the image analysis software FreeSurfer, was performed. Cortical thickness and volume of subcortical structures was examined with a multivariate method (scaled subprofile modeling) which produces patterns of areas related to the disorder. Analysis of difference between patients compared to healthy controls and correlation to symptom severity, measured with the Childrens Yale-Brown Obsessive-Compulsive Scale (CYBOCS), were performed. A significant correlation between cortical thickness and CYBOCS was found. Areas of major effect in the corresponding pattern included the left fusiform gyrus and the left parietal lobe.

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