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Abstract #2002

Multiparametric MRI characterization of NBO treatment following mild Traumatic Brain Injury

Justin Alexander Long 1 , Lora Talley Watts 1 , Jonathan Chemello 1 , Qiang Shen 1 , Shiliang Huang 1 , and Timothy Duong 1

1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

This study investigated the spatiotemporal dynamics of diffusion, T2 and fractional anisotropy associated with mild traumatic brain injury (TBI) following NBO treatment. Diffusion, T2 and fractional anisotropy changes generally indicated that lesion severity increased following administration of NBO treatment compared to the air treated control group. T2 increased in the NBO treatment groups initially (3 hrs and day 1 measures), returning to similar magnitude as the air treated control group by Day 2 and then showed a significant increase by 14 days post injury. ADC and FA differences were significant at all time points. Multi-parametric MRI offers a range of biomarkers that are sensitive to different tissue types at different stages of TBI and can distinguish differences in outcome based on treatments applied.

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