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Abstract #2009

Diffusion and Perfusion Imaging in Repeated Concussion

David K Wright 1,2 , Jack Trezise 3 , Leigh A Johnston 1,4 , Roger Ordidge 2 , Terence J O'Brien 3 , and Sandy R Shultz 3

1 The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia, 2 Department of Anatomy and Neuroscience, The University of Melbourne, Parkville, Victoria, Australia, 3 Department of Medicine, Royal Melbourne Hospital, Victoria, Australia, 4 Neuroengineering Laboratory, Department of Electrical and Electronic Engineering, The University of Melbourne, Victoria, Australia

Although a single brain concussion rarely has lasting effects, recurrent concussions may result in cumulative chronic neurological and neuropsychiatric impairments. The current clinical management of concussion is based on assessing for the resolution of neurocognitive impairments, however an asymptomatic state may not accurately indicate that the brain has fully recovered. Here we investigate the potential of magnetic resonance imaging (MRI) as a platform in assessing the brain effects of concussion. The results show MRI to be sensitive to the subtle pathophysiological changes that occur in the concussed brain and contribute to the cumulative and degenerative effects of repeated concussion.

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