Diffusion and Perfusion Imaging in Repeated Concussion
David K Wright 1,2 , Jack Trezise 3 , Leigh A Johnston 1,4 , Roger Ordidge 2 , Terence J O'Brien 3 , and Sandy R Shultz 3
The Florey Institute of Neuroscience and
Mental Health, Parkville, Victoria, Australia,
of Anatomy and Neuroscience, The University of
Melbourne, Parkville, Victoria, Australia,
of Medicine, Royal Melbourne Hospital, Victoria,
Laboratory, Department of Electrical and Electronic
Engineering, The University of Melbourne, Victoria,
Although a single brain concussion rarely has lasting
effects, recurrent concussions may result in cumulative
chronic neurological and neuropsychiatric impairments.
The current clinical management of concussion is based
on assessing for the resolution of neurocognitive
impairments, however an asymptomatic state may not
accurately indicate that the brain has fully recovered.
Here we investigate the potential of magnetic resonance
imaging (MRI) as a platform in assessing the brain
effects of concussion. The results show MRI to be
sensitive to the subtle pathophysiological changes that
occur in the concussed brain and contribute to the
cumulative and degenerative effects of repeated
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