Abstract #2029
Serial changes in Apparent Diffusion Coefficient in Acute Ischemic Stroke
George William John Harston 1 , Jacob Levman 2 , Thomas Okell 3 , George Pope 4 , Ian Reckless 4 , Fintan Sheerin 4 , Martino Cellerini 4 , Stephen Payne 2 , Michael Chappell 2 , Peter Jezzard 3 , and James Kennedy 1
1
Radcliffe Department of Medicine, University
of Oxford, Oxford, Oxfordshire, United Kingdom,
2
Department
of Engineering Science, University of Oxford, Oxford,
Oxfordshire, United Kingdom,
3
Nuffield
Department of Clinical Neurosciences, University of
Oxford, Oxford, Oxfordshire, United Kingdom,
4
Oxford
University Hospitals NHS Trust, Oxford, Oxfordshire,
United Kingdom
Diffusion-weighted imaging, using the apparent diffusion
coefficient (ADC), is the current imaging gold standard
to define infarction acutely for patients with ischemic
stroke. The natural history of this biomarker is debated
and its validity in defining infarction has been
challenged. In this study repeated measures of ADC were
systematically taken from a cohort of patients with
ischemic stroke to explore the changes of this biomarker
over time. It was found that ADC lesion reversal within
24 hours does not predict sustained tissue recovery, but
a small proportion of tissue with abnormal ADC at 24
hours will recover by 1 month.
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