Vasospasm and phlebectasia following subarachnoid hemorrhage
Yuhao Sun 1,2 , Qiang Shen 1 , Shiliang Huang 1 , and Timothy Q Duong 1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
Texas, United States,
of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong
University School of Medicine, Shanghai, China
Vasospasm is a hallmark of human SAH and needs to be
treated promptly. Similar animal MRI studies of
vasospasm in SAH are sparse. Moreover, SAHs effects on
veins remain unknown in SAH patients and animal models
of SAH. This study investigated the effects of SAH on
cerebral arteries and veins in rats using MRA and MRV.
SAH caused severe time-dependent arterial vasospasm. SAH
also increased venous volume, impeding vein reflux.
These changes likely play a role in early brain injury
in SAH. Our studies point to an additional and
underappreciated set of physiologic effects that are
caused by subarachnoid hemorrhage.
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