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Abstract #2033

Vasospasm and phlebectasia following subarachnoid hemorrhage

Yuhao Sun 1,2 , Qiang Shen 1 , Shiliang Huang 1 , and Timothy Q Duong 1

1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States, 2 Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Vasospasm is a hallmark of human SAH and needs to be treated promptly. Similar animal MRI studies of vasospasm in SAH are sparse. Moreover, SAHs effects on veins remain unknown in SAH patients and animal models of SAH. This study investigated the effects of SAH on cerebral arteries and veins in rats using MRA and MRV. SAH caused severe time-dependent arterial vasospasm. SAH also increased venous volume, impeding vein reflux. These changes likely play a role in early brain injury in SAH. Our studies point to an additional and underappreciated set of physiologic effects that are caused by subarachnoid hemorrhage.

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