Atypical BOLD fMRI response is co-localized with abnormal resting perfusion in patients with arteriovenous malformations
Erin L Mazerolle 1 , Roberta La Piana 2 , Donatella Tampieri 2 , Kelvin Mok 2 , Maria Cortes 2 , Denise Klein 2 , and G Bruce Pike 1
University of Calgary, Calgary, Alberta,
Neurological Institute, Montreal, Quebec, Canada
Pre-treatment mapping has become an established clinical
application of blood oxygen level dependent (BOLD) fMRI.
However, in patients with abnormal perfusion such as
arteriovenous malformations (AVMs), it can be difficult
to interpret BOLD results. We used arterial spin
labelling (ASL) to evaluate whether perfusion
information can clarify the interpretation of atypical
fMRI responses in AVM patients. We found that atypical
BOLD functional connectivity and activation was
preferentially localized to regions of abnormally high
perfusion. We propose that clinical applications of BOLD
in patients with abnormal cerebral hemodynamics could
greatly benefit from additional measurements such as ASL.
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