Abstract #2035
Atypical BOLD fMRI response is co-localized with abnormal resting perfusion in patients with arteriovenous malformations
Erin L Mazerolle 1 , Roberta La Piana 2 , Donatella Tampieri 2 , Kelvin Mok 2 , Maria Cortes 2 , Denise Klein 2 , and G Bruce Pike 1
1
University of Calgary, Calgary, Alberta,
Canada,
2
Montreal
Neurological Institute, Montreal, Quebec, Canada
Pre-treatment mapping has become an established clinical
application of blood oxygen level dependent (BOLD) fMRI.
However, in patients with abnormal perfusion such as
arteriovenous malformations (AVMs), it can be difficult
to interpret BOLD results. We used arterial spin
labelling (ASL) to evaluate whether perfusion
information can clarify the interpretation of atypical
fMRI responses in AVM patients. We found that atypical
BOLD functional connectivity and activation was
preferentially localized to regions of abnormally high
perfusion. We propose that clinical applications of BOLD
in patients with abnormal cerebral hemodynamics could
greatly benefit from additional measurements such as ASL.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
