Abstract #2056
Corticospinal Tract Degeneration Correlates with Clinical Disability in Multiple Sclerosis
Sanjeev Chawla 1 , Ilya Kister 2 , Robert I Grossman 1 , and Yulin Ge 1
1
Radiology, New York University Langone
Medical Center, New York, NY, United States,
2
Neurology,
New York University Langone Medical Center, New York,
NY, United States
The purpose of present study was to determine fiber
degeneration along the course of corticospinal tract
(CST) in a cohort of 33 patients with multiple sclerosis
(MS) who alongwith 17 controls underwent diffusion
tensor imaging. Significant reduction in fractional
anisotropy (FA) and elevation in mean diffusivity (MD)
alongwith trends towards increase in axial and radial
diffusivities were observed in patients compared to
controls. Combination of MD and FA provided sensitivity
of 88.2% and specificity of 63.6% to distinguish two
groups. A significant inverse correlation between FA and
EDSS was observed. Our study demonstrates quantitative
structural degeneration of CST in MS.
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