Abstract #2067
Direct Detection of Myelin Using Zero-Echo Time (ZTE) Imaging in Lamb Spinal Cord
Cheng Li 1 , Alan C. Seifert 1 , Suzanne L. Wehrli 2 , Michael J. Wilhelm 3 , David B. Hackney 4 , and Felix W. Wehrli 1
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
2
NMR
Core Facility, Childrens Hospital of Philadelphia,
Philadelphia, PA, United States,
3
Chemistry,
Temple University, Philadelphia, PA, United States,
4
Radiology,
Harvard Medical School, Boston, MA, United States
Direct assessment of myelin would reveal central nervous
system (CNS) abnormalities and enhance our understanding
of neurological diseases. Our previous work demonstrated
that myelin can be directly imaged on a 9.4T NMR
laboratory spectrometer/imaging system with ultra-short
echo time (UTE) imaging. However, the extremely short T2
values (~100s) and relatively low proton density of
myelin limit its detectability on clinical scanner. In
this work, we demonstrate the feasibility of
quantitative zero-echo time (ZTE) imaging of
reconstituted extracted myelin and intact lamb spinal
cord at 9.4T and on a 3T whole-body scanner.
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