Abstract #2070
Longitudinal mixed-effect model analysis of the association between global and tissue specific brain atrophy and lesion accumulation in patients with CIS
Mihael Varosanec 1 , Dana Horakova 2 , Jesper Hagemeier 1 , Niels Bergsland 1 , Michaela Tyblova 2 , Zdenek Seidl 3 , Manuela Vaneckova 3 , Jan Krasensky 3 , Michael G. Dwyer 1 , Eva Havrdova 2 , and Robert Zivadinov 1
1
Buffalo Neuroimaging Analysis Center,
Department of Neurology, University at Buffalo SUNY,
Buffalo, NY, United States,
2
Department
of Neurology and Center of Clinical Neuroscience,
Charles University in Prague, Prague, Czech Republic,
3
Department
of Radiology, First Faculty of Medicine and General
University Hospital, Charles University in Prague,
Prague, Czech Republic
We investigated accumulation of new brain lesion, lesion
volume, and contrast enhancing lesions with respect to
the atrophy of gross brain structures in patients with
clinically isolated syndrome. Longitudinal linear and
quadratic mixed effect model analyses were performed for
each time point and in dual directions. The more robust
inverse mixed-effect model results suggest that the
level of brain atrophy can explain T2 lesion
accumulation better than the T2 lesion accumulation can
explain accumulation of brain atrophy. These results
suggests that close monitoring of brain volume changes
may be relevant for identifying patients at risk for MS
conversion.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
