Abstract #2092
Regional differences in viscoelasticity in normal and inflamed mouse brain
Jing Guo 1 , Juergen Braun 2 , Dominique Berndt 3 , Carmen Infante-Duarte 3,4 , Ingolf Sack 1 , and Jason M. Millward 3,4
1
Department of Radiology, Charite -
Universitaetsmedizin Berlin, Berlin, Berlin, Germany,
2
Department
of Medical Informatics, Charite - Universitaetsmedizin
Berlin, Berlin, Germany,
3
Department
of Medical Immunology, Charite - Universitaetsmedizin
Berlin, Berlin, Germany,
4
Experimental
and Clinical Research Center,
Charite-Universitaetsmedizin Berlin and the
Max-Delbrueck Center for Molecular Medicine Berlin,
Berlin, Germany
We applied MRE to study regional differences in
viscoelasticity in normal and inflamed mouse brain. In
normal mouse brain, we found that the posterior region
(comprising cerebellum and brainstem) is softer than the
anterior region in a midsagittal slice. We also examined
the alterations in G' of the GKO mice where more
cerebellum involvement is expected during EAE, we
observed the reduction in G' during the course of
disease and a significant increase in the ratio of G'
between the posterior and anterior part of the brain at
day 14, which may relate to the infiltration of immune
cells.
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