Abstract #2094
Lack of dystrophin results in abnormal cerebral water exchange and perfusion in vivo
Candida L Goodnough 1 , Ying Gao 2 , Xin Li 2 , L. Henry Goodnough 3 , Chris A Flask 2,4 , and Xin Yu 2
1
Physiology, Case Western Reserve University,
Cleveland, OH, United States,
2
Biomedical
Engineering, Case Western Reserve University, OH, United
States,
3
Pathology,
Case Western Reserve University, oh, United States,
4
Radiology,
Case Western Reserve University, Cleveland, OH, United
States
Dystrophin, a component of the dystrophin-glycoprotein
complex, plays a role in the formation and function of
the blood-brain barrier (BBB). The absence of dystrophin
has been shown to lead to a leaky BBB and enhanced
arteriogenesis in vitro. To elucidate the function of
dystrophin in maintaining water balance and perfusion at
the BBB in vivo, we characterized the effect of
dystrophin disruption on cerebral perfusion and water
exchange across BBB using arterial spin labeling and
diffusion-weighted MRI in dystrophin-deficient mice
versus wild-type. Our results demonstrate a reduction in
diffusion and increase in perfusion associated with the
absence of dystrophin.
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