Meeting Banner
Abstract #2094

Lack of dystrophin results in abnormal cerebral water exchange and perfusion in vivo

Candida L Goodnough 1 , Ying Gao 2 , Xin Li 2 , L. Henry Goodnough 3 , Chris A Flask 2,4 , and Xin Yu 2

1 Physiology, Case Western Reserve University, Cleveland, OH, United States, 2 Biomedical Engineering, Case Western Reserve University, OH, United States, 3 Pathology, Case Western Reserve University, oh, United States, 4 Radiology, Case Western Reserve University, Cleveland, OH, United States

Dystrophin, a component of the dystrophin-glycoprotein complex, plays a role in the formation and function of the blood-brain barrier (BBB). The absence of dystrophin has been shown to lead to a leaky BBB and enhanced arteriogenesis in vitro. To elucidate the function of dystrophin in maintaining water balance and perfusion at the BBB in vivo, we characterized the effect of dystrophin disruption on cerebral perfusion and water exchange across BBB using arterial spin labeling and diffusion-weighted MRI in dystrophin-deficient mice versus wild-type. Our results demonstrate a reduction in diffusion and increase in perfusion associated with the absence of dystrophin.

This abstract and the presentation materials are available to members only; a login is required.

Join Here