Abstract #2096
Nigrostriatal pathway evaluation with diffusion MRI and three-dimensional histological analysis in a monkey model of Parkinson s disease
Keigo Hikishima 1,2 , Kiyoshi Ando 1 , Ryutaro Yano 3 , Yuji Komaki 1,2 , Kenji Kawai 1 , Takashi Inoue 1 , Masayuki Yamada 4 , Toshio Itoh 1 , Suketaka Momoshima 5 , Hirotaka James Okano 6 , and Hideyuki Okano 2
1
Central Institute for Experimental Animals,
Kawasaki, Kanagawa, Japan,
2
Department
of Physiology, Keio University School of Medicine,
Shinjuku, Tokyo, Japan,
3
Faculty
of Health Sciences, Tokyo Metropolitan University,
Tokyo, Japan,
4
School
of Health Science, Fujita Health University, Aichi,
Japan,
5
Department
of Diagnostic Radiology, Keio University School of
Medicine, Tokyo, Japan,
6
Division
of Regenerative Medicine, Jikei University School of
Medicine, Tokyo, Japan
Movement dysfunction in Parkinsonfs disease is caused
by the degeneration of dopaminergic neurons in the
substantia nigra pars compacta. We used a microscopic
diffusion tensor tractography (DTT) technique with an
isotropic resolution of 60 m and three-dimensional
histological analysis to visualize the nigrostriatal
pathway in the common marmoset, a small non-human
primate. We also developed longitudinal voxel-based
analysis to detect the distribution of degeneration. In
this study, we report that microscopic DTT visualized
the nigrostriatal pathway and longitudinal voxel-based
analysis assessed neuronal degeneration in a monkey
model of Parkinsonfs disease.
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