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Abstract #2102

Metabolic Alterations in Rat Brain due to Chronic High Altitude Stress: A 1H-MRS study

Sunil Koundal 1 , Sonia Gandhi 1 , Tanzeer Kaur 2 , Rajendra P Tripathi 1 , and Subash Khushu 1

1 NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), Timarpur, Delhi, India, 2 Department of Biophysics, Panjab University, Chandigarh, India

Neurometabolic alterations in response to chronic high altitude stress were studied with 1H-MR Spectroscopy. Inositol and choline concentrations were significantly decreased after 7 and 14 days of altitude exposure which was linked to altered astrocyte metabolism and neuronal rescue effort respectively. A significant decrease in Glutamate+Glutamine after 14 day hypoxia reflected altered glutamate metabolism. An increment in taurine reflects protective effect from excitotoxic injury. There was no significant NAA change, implying retained neuronal integrity. This study along with in vitro High resolution NMR spectroscopy and other biochemical analysis may provide better insights of the injury and possible interventions.

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