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Abstract #2123

Diffusion MRI in Crohn's Disease: Comparison with Fecal Calprotectin and MR-Enterography

Douglas Andrew Pendse 1 , Jesica Makanyanga 1 , Andrew Plumb 1 , David Atkinson 1 , and Stuart Taylor 1

1 Centre for Medical Imaging, University College London, London, London, United Kingdom

Therapeutic strategies in Crohns disease are dependent on both the degree of disease activity and the overall burden of disease in the gut. In this study we evaluated diffusion MRI (DWI) of the bowel in 69 adult patients with Crohns disease, using validated methods of MEGS score on MR-Enterography (MRE) and fecal Calprotectin (fC) as reference standards. Patients with abnormal DWI were shown to have significantly higher levels of fC and had higher MEGS score on conventional MRE. These data suggest that diffusion MRI is a clinically useful tool in the evaluation of Crohns activity.

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