Abstract #2143
Quantification of total adipose tissue in fetal guinea pigs subjected to suboptimal in utero conditions using water-fat MRI
Kevin J Sinclair 1 , Lanette J Friesen-Waldner 1 , Colin M McCurdy 1 , Curtis N Wiens 2 , Trevor P Wade 1,3 , Barbra de Vrijer 4 , Timothy RH Regnault 4,5 , and Charles A McKenzie 1,3
1
Department of Medical Biophysics, University
of Western Ontario, London, Ontario, Canada,
2
Department
of Radiology, University of Wisconsin, Madison,
Wisconsin, United States,
3
Robarts
Research Institute, University of Western Ontario,
London, Ontario, Canada,
4
Department
of Obstetrics and Gynaecology, University of Western
Ontario, London, Ontario, Canada,
5
Department
of Physiology and Pharmacology, University of Western
Ontario, London, Ontario, Canada
The metabolic syndrome is a cluster of morbidities that
lead to an increased risk of developing cardiovascular
disease. Studies suggest that the propensity to develop
the metabolic syndrome can be programmed during fetal
development. In this study, adipose tissue distributions
in guinea pig fetuses were monitored using water-fat
MRI. The fetuses were subjected to 3 different in utero
conditions: over-nourishment, under-nourishment, and
appropriate nourishment of the fetus. T1- and
T2-weighted, as well as IDEAL water-fat images were
acquired. Increased total adipose tissue was seen in the
over-nourished case, while under-nourished fetuses had
decreased total adipose tissue compared to normal.
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