Abstract #2150
MR Tagging based cardiac-induced liver deformation analysis in murine model of non-alcoholic fatty liver disease
Anna Osiak 1 , Krzysztof Jasinski 1 , Pawel T. Jochym 2 , Edyta Maslak 3 , and Tomasz Skorka 1
1
Department of Magnetic Resonance Imaging,
Institute of Nuclear Physics Polish Academy of Sciences,
Krakw, Poland,
2
Department
of Materials Research by Computers, Institute of Nuclear
Physics Polish Academy of Sciences, Krakw, Poland,
3
Department
of Endothelium Experimental Pharmacology, Jagiellonian
Center for Experimental Therapeutics (JCET), Krakw,
Poland
The objective was to assess cardiac-induced liver
deformation in murine model of non-alcoholic fatty liver
disease (NAFLD) using MR Tagging. Control and NAFLD mice
were examined and liver tissue displacements Disp, E1
and E2 principal strains were computed within 7 regions
and normalized to maximum heart declination. In NAFLD
the tissue compression increased, maximum Disp and E1
were preserved, but the deformation were propagated
deeper in the organ compared to controls, what may
reflect increased fat deposition at non-fibrotic stage
of pathology. Good consistency of the results suggests
the routine may be helpful for evaluation of fat
deposition degree.
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