T1 mapping on gadoxetate disodium enhanced MRI in patients with primary sclerosing cholangitis (PSC)

In our prospective study we sought to assess the value of T1-mapping of the liver on gadoxetate-disodium enhanced MRI in patients with PSC. In 40 patients T1-mapping of the whole liver was performed using a 3D GRE-sequence with different flip angles before and after contrast injection. T1 relaxation times in all liver segments were assessed and correlated with liver function tests. T1 relaxation times after contrast injection significantly decreased and correlated with bilirubin, cholinesterase and GOT. Our findings may be useful for dynamic evaluation and follow-up of patients with PSC, as well as for guidance of biopsies.

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