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Abstract #2163

Pharmakokinetic modeling and quantification of the liver function using DCE-MRI with contrast agent Gd-EOB-DTPA

Patrick Zylka 1 , Timm Denecke 2 , Dominik Geisel 2 , and Lutz Ldemann 1

1 Klinik und Poliklinik fr Strahlentherapie, Universittsklinikum Essen, Essen, NRW, Germany, 2 Klinik fr Radiologie, Charit Universittsmedizin Berlin, Berlin, NRW, Germany

We investigate the possibility to establish a mathematical model which is able to describe liver parameters noninvasive and space-resolved by magnetic resonance imaging (DCE-MRI). We use Gd-EOB-DTPA as contrast agent which is metabolized by healthy hepatocytes whereas the metabolism of damaged cells is strongly suppressed. Determing the rate of metabolism we can compare liver regions to quantify the degree of function loss. After converting voxel signal to relaxation rate (which is proportional to the contrast agent concentration), the data of a chosen liver area is handed to a computer program. The algorithm is based on a two-compartment-model and returns the parameters "overall flow", mean transit time, "hepatic input / extraction rate" as well as the compartment volumes.

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