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Abstract #2168

Quantitative perfusion of hepatocellular carcinoma before and after Y-90 radioembolization using a MR angiographic technique with multi-echo and radial k-space sampling

N. Chatterjee 1,2 , R. J. Lewandowski 1 , E. Semaan 1 , R. Salem 1 , R. Ryu 1 , K. Sato 1 , F. Miller 1 , J. C. Carr 1 , T. J. Carroll 1,2 , and J. D. Collins 1

1 Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, 2 Department of Biomedical Engineering, Northwestern University, Chicago, IL, United States

Assessing early HCC treatment response following Y-90 RAE is often challenging using conventional CT and MR techniques due to lesion enlargement and heterogeneous peripheral contrast enhancement. Quantitative assessment of the necrotic core (EASL criteria) has shown promise for predicting response to therapy. We present early data evaluating quantitative target lesion perfusion using a radially sampled CE-MRA sequence employing echo-sharing to achieve a 64-fold temporal acceleration and an effective temporal resolution of 45msec. Preliminary results demonstrate that hyperemic effects of regional liver radiation injury raises the absolute target lesion perfusion, requiring normalization to either remote or adjacent liver parenchymal perfusion.

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