Quantitative perfusion of hepatocellular carcinoma before and after Y-90 radioembolization using a MR angiographic technique with multi-echo and radial k-space sampling
N. Chatterjee 1,2 , R. J. Lewandowski 1 , E. Semaan 1 , R. Salem 1 , R. Ryu 1 , K. Sato 1 , F. Miller 1 , J. C. Carr 1 , T. J. Carroll 1,2 , and J. D. Collins 1
Department of Radiology, Northwestern
University Feinberg School of Medicine, Chicago, IL,
of Biomedical Engineering, Northwestern University,
Chicago, IL, United States
Assessing early HCC treatment response following Y-90
RAE is often challenging using conventional CT and MR
techniques due to lesion enlargement and heterogeneous
peripheral contrast enhancement. Quantitative assessment
of the necrotic core (EASL criteria) has shown promise
for predicting response to therapy. We present early
data evaluating quantitative target lesion perfusion
using a radially sampled CE-MRA sequence employing
echo-sharing to achieve a 64-fold temporal acceleration
and an effective temporal resolution of 45msec.
Preliminary results demonstrate that hyperemic effects
of regional liver radiation injury raises the absolute
target lesion perfusion, requiring normalization to
either remote or adjacent liver parenchymal perfusion.
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