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Abstract #2190

Arterial transit time-corrected renal blood flow measurement by pulsed continuous arterial spin labeling MRI: a feasibility and validation study in healthy volunteers

Kazuhiro Shimizu 1 , Nobuyuki Kosaka 1 , Yasuhiro Fujiwara 1 , Tsuyoshi Matsuda 2 , Tatsuya Yamamoto 1 , Tatsuro Tsuchida 1 , Katsuki Tsuchiyama 3 , Nobuyuki Oyama 3 , and Hirohiko Kimura 1

1 Department of Radiology, University of Fukui, Eiheiji, Fukui, Japan, 2 Global MR Applications and Workflow, GE Healthcare Japan, Hino, Tokyo, Japan, 3 Department of Urology, University of Fukui, Eiheiji, Fukui, Japan

We evaluated the feasibility of pulsed continuous arterial spin labeling (pcASL) MRI with multiple post-label-delay (PLD) acquisition for measuring arterial transit time (ATT)-corrected renal blood flow (ATC-RBF) in healthy volunteers. Significant differences were seen between younger and older groups in ATC-RBF and ATT, and kidney volume-corrected ATC-RBF (ATC-cRBF) correlated significantly with effective renal plasma flow (ERPF), as measured by 99mTc-MAG3 scintigraphy. However, the only moderate correlation between ATC-cRBF and ERPF suggests that further technical development may be required for RBF quantification by pcASL MRI.

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