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Abstract #2206

Parametric Mapping of Renal T2* Demonstrates Beneficial Effect of Epoxyeicosatrienoic Acid for Preventing Acute Kidney Injury

Andreas Pohlmann 1 , Jan Hentschel 1 , Uwe Hoff 2 , Gordana Bubalo 2 , Mandy Fechner 2 , Maximilian Blum 3 , Ye Zhu 2 , Karen Arakelyan 1,4 , Erdmann Seeliger 4 , Bert Flemming 4 , Dennis Gurgen 2 , Wolfgang Schneider 3 , Michael Rothe 5 , Vijaya L Manthati 6 , John R Falck 6 , Wolf-Hagen Schunck 3 , Duska Dragun 2 , and Thoralf Niendorf 1

1 Berlin Ultrahigh Field Facility, Max Delbrueck Center for Moleculare Medicine, Berlin, Germany, 2 Nephrology and Intensive Care Medicine, Campus Virchow-Klinikum and Center for Cardiovascular Research, Charite-Universitaetsmedizin Berlin, Berlin, Germany, 3 Experimental and Clinical Research Center, Charite Medical Faculty and the Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 4 Institute of Physiology and Center for Cardiovascular Research, Charit Medical Faculty, Berlin, Germany, 5 Lipidomix GmbH, Berlin, Germany, 6 Biochemistry Department, UT Southwestern, Dallas, TX, United States

Current therapeutic options for treating acute kidney injury (AKI) are disappointing and hence the need for establishing druggable targets. Imbalances in cytochrome P450 (CYP)-dependent eicosanoid formation may play a central role in AKI. Imbalance between renal oxygen demand and supply is considered to be the initiating step in the pathophysiologic cascade of events. In this study we investigated whether administration of an epoxyeicosatrienoic acid (EET) agonist improves renal reoxygenation during the initial 2 h reperfusion phase. Parametric mapping of renal T2* demonstrated improved renal re-oxygenation after EET treatment. EET agonists may provide novel therapeutic options for prevention of ischemic AKI.

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