Abstract #2208
High Resolution Hyperpolarized 13 C Urea MRI Renography
Galen D Reed 1 , Cornelius von Morze 1 , Bertram L Koelsch 1 , Myriam M Chaumeil 1 , Alan S Verkman 2 , Sabrina M Ronen 1 , Robert A Bok 1 , Jeff M Sands 3 , Peder E Larson 1 , Jan Henrik Ardenkjaer-Larsen 4 , John Kurhanewicz 1 , and Daniel B Vigneron 1
1
Radiology and Biomedical Imaging, University
of California San Francisco, San Francisco, California,
United States,
2
Nephrology,
University of California San Francisco, San Francisco,
California, United States,
3
Department
of Medicine, Renal Division, Emory University, Atlanta,
Georgia, United States,
4
Electrical
Engineering, Technical University of Denmark, Lyngby,
Denmark
Urea is a key osmolyte that plays a crucial role in
kidney function. In this study, we present a
hyperpolarized
13
C
MRI method for imaging urea within the renal tubules and
collecting system at 1.2 mm isotropic resolution. This
method utilizes the increased urea T
2
from
15
N
labeling combined with specialized 3D SSFP acquisition
and the very large
13
C
urea T
2
contrast
observed between the kidney and vasculature. Relaxometry
experiments revealed this long-T
2
signal
reports on urea that has passed through the glomerulus,
thus enabling renal urea filtration as a source of image
contrast.
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