Abstract #2229
Assessment of Intrahepatic Lipid Composition during Calorie Restriction and Exercise Intervention in Diet Induced Obese Rats by MRS
Venkatesh Gopalan 1 , Jadegoud Yaligar 1 , Swee Shean Lee 1 , Navin Michael 2 , and S Sendhil Velan 1,2
1
Laboratory of Molecular Imaging, Singapore
Bioimaging Consortium, Singapore, Singapore,
2
Singapore
Institute for Clinical Sciences, Singapore, Singapore
Hepatic fat plays a major role in metabolic diseases
including obesity, diabetes, and non-alcoholic fatty
liver disease (NAFLD). In vivo magnetic resonance
spectroscopy (MRS) permits non-invasive longitudinal
assessment of fat fraction, saturated and unsaturated
lipids. Interventions including exercise and calorie
restriction play a major role in anti-obesity and also
for recovery from NAFLD. In the current study we have
estimated the changes in intrahepatic lipid content
including, fat fraction, total unsaturated lipids (TUL),
fraction of unsaturated lipid (fUL) and unsaturation
index (UI) in five groups of high fat diet (HFD) fed
obese rat model with exercise and calorie restriction
interventions. Our preliminary results suggest
significant reduction and modulation of intrahepatic
lipids with exercise and calorie restriction.
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