Assessment of reproducibility of IVIM based perfusion fraction and diffusion coefficient in the pancreas
Oliver J. Gurney-Champion 1 , Martijn Froeling 2 , Remy Klaassen 1 , Jaap Stoker 1 , Geertjan van Tienhoven 1 , Hanneke W.M. van Laarhoven 1 , Arjan Bel 1 , and Aart J. Nederveen 1
Academic Medical Center, Amsterdam,
Medical Center Utrecht, Netherlands
The perfusion fraction, f, obtained from intravoxel
incoherent imaging can potentially be used as biomarker
to distinguish between pancreatic carcinomas and healthy
tissue. Using an optimized imaging sequence, together
with an in-house post-processing toolkit in eight
healthy volunteers, we show a good reproducibility for f
(RI=17%) and diffusion coefficient, D, (RI=13%).
Averaging over all volunteers we found D=1.400.07x10-3
mm3/s, f=9.41.8 % and pseudo-diffusion coefficient
D*=0.0871 mm3/s . We showed how the RI decreases for
decreasing number of averages. Finally, for one patient,
we could observe a difference in f between healthy and
tumorous pancreas tissue.
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