Abstract #2246
Robust Diffusion-Weighted Single-Shot MRI Can Resolve Major Mice Placental Compartments
Eddy Solomon 1 , Reut Avni 2 , Peter Bendel 3 , Lucio Frydman 1 , and Michal Neeman 2
1
Chemical Physics, Weizmann Institute of
Science, Rehovot, Israel,
2
Biological
Regulation, Weizmann Institute of Science, Rehovot,
Israel,
3
Chemical
Research Support, Weizmann Institute of Science,
Rehovot, Israel
Novel diffusion-based MRI methodologies relying on
SPatio-temporal ENcoding (SPEN) were developed, and used
to uncover in-vivo aspects about the diffusion of fluids
in mouse placenta. Macromolecular contrast agents were
used to distinguish the ADCs of maternal blood
capillaries, fetal blood capillaries and trophblast
giant cells. Significantly, different diffusion and
perfusion properties were thus noticed, spanning nearly
two orders of magnitude. This yields a new
multiparametric view of the placenta whereby mainly free
diffusion occurs in the maternal blood, a strongly
forced perfusion is observed in the fetal
microcapillaries, and moderate fluid exchanges
characterizes the trophoblasts lining the maternal blood
pool.
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