Diastolic Dysfunction Is Temporally Dissociated from Myocardial Steatosis

The risk for heart failure in obesity and diabetes is greater than can be accounted for by traditional factors of hypertension and coronary artery disease. Altered substrate metabolism may contribute to dysfunction of diabetic heart. In obesity and diabetes contribution of glucose oxidation to cardiac energetics is sub-normal with enhanced reliance on fatty acid metabolism. Most work in cardiac metabolism has been performed in rodent models. We present results from a study in which we altered cardiac metabolism by 48 hours fasting in humans. Cardiac metabolism was assessed by myocardial triglyceride content and diastolic function assessed by myocardial tissue tagging.

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