Abstract #2311
Oxygen-dependence of T 1 in lung tissue as observed in isolated, ventilated porcine lung phantoms
Simon Triphan 1,2 , Bertram Jobst 1,3 , Paul Flechsig 1,3 , Felix Breuer 2 , Peter Jakob 2 , and Jrgen Biederer 1,4
1
Diagnostic and Interventional Radiology,
University Hospital Heidelberg, Heidelberg,
Baden-Wrttemberg, Germany,
2
Research
Centre Magnetic Resonance Bavaria e.V., Wrzburg,
Bayern, Germany,
3
Translational
Lung Research Center Heidelberg, Member of the German
Lung Research Center (DZL), Heidelberg,
Baden-Wrttemberg, Germany,
4
German
Cancer Research Center (DKFZ), Heidelberg,
Baden-Wrttemberg, Germany
T
1
,
the T
1
-reduction induced by breathing pure
oxygen, has been used for lung functional imaging. While
this effect is primarily attributed to molecular oxygen
(O
2
) dissolved in blood, the same also occurs
in tissue.
T
1
thus
provides a measure of lung function comprised of various
aspects. The T
1
reduction
in tissue alone was examined using porcine lung explants
in air and oxygen atmosphere. T
1
reductions
of 12%, similar to those observed
in
vivo
were
measured. T
1
in
the bloodless explants was found to be significantly
shorter than
in
vivo
. Additionally, a measurement of a preserved
explant yielded even smaller T
1
and
T
1
.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.