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Abstract #2311

Oxygen-dependence of T 1 in lung tissue as observed in isolated, ventilated porcine lung phantoms

Simon Triphan 1,2 , Bertram Jobst 1,3 , Paul Flechsig 1,3 , Felix Breuer 2 , Peter Jakob 2 , and Jrgen Biederer 1,4

1 Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Baden-Wrttemberg, Germany, 2 Research Centre Magnetic Resonance Bavaria e.V., Wrzburg, Bayern, Germany, 3 Translational Lung Research Center Heidelberg, Member of the German Lung Research Center (DZL), Heidelberg, Baden-Wrttemberg, Germany, 4 German Cancer Research Center (DKFZ), Heidelberg, Baden-Wrttemberg, Germany

Capital Greek Delta T 1 , the T 1 -reduction induced by breathing pure oxygen, has been used for lung functional imaging. While this effect is primarily attributed to molecular oxygen (O 2 ) dissolved in blood, the same also occurs in tissue. Capital Greek Delta T 1 thus provides a measure of lung function comprised of various aspects. The T 1 reduction in tissue alone was examined using porcine lung explants in air and oxygen atmosphere. T 1 reductions of 12%, similar to those observed in vivo were measured. T 1 in the bloodless explants was found to be significantly shorter than in vivo . Additionally, a measurement of a preserved explant yielded even smaller T 1 and Capital Greek Delta T 1 .

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