Abstract #2313
Backflow variability shows importance of MR monitoring of CED infusions
Ethan K. Brodsky 1,2 , Benjamin Grabow 1 , Martin L. Brady 3 , Raghu Raghavan 3 , Chris D. Ross 4 , and Walter F. Block 1,2
1
Medical Physics, University of Wisconsin,
Madison, WI, United States,
2
Biomedical
Engineering, University of Wisconsin, Madison, WI,
United States,
3
Therataxis,
LLC, Baltimore, MD, United States,
4
Engineering
Resources Group, Inc., Pembroke Pines, FL, United States
Convection-enhanced delivery (CED) is a neurosurgical
procedure for delivering large molecular and viral
vectors into the brain. Its effectiveness has been
somewhat limited, however, by unexplained variability,
with two identical infusion protocols sometimes
generating very different drug distributions. We have
completed a comprehensive study on the use of real-time
MR monitoring to unravel often conflicting
recommendations on the design of infusion catheters,
flow rates, and other techniques to minimize variance in
drug distribution. Specifically, we present results here
regarding an investigation to minimize variations in
drug distribution due to unwanted loss of infusate
through a low pressure escape route along the exterior
of the catheter, termed backflow.
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