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Abstract #2332

Correction for the Oblique Focus in MR-Guided Focused Ultrasound for the Treatment of Essential Tremor

Yuexi Huang 1 , Alec Hughes 2 , Michael L. Schwartz 3 , Andres M. Lozano 4 , and Kullervo Hynynen 1,2

1 Sunnybrook Research Institute, Toronto, ON, Canada, 2 Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3 Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4 Division of Neurosurgery, Toronto Western Hospital, Toronto, ON, Canada

Magnetic resonance guided focused ultrasound has shown promising results in the treatment of essential tremor. MR-based targeting and temperature monitoring ensured precise lesioning of the ventral intermediate nucleus (VIM) in the thalamus. However, although the centres of VIM were precisely targeted, oblique lesion volumes angled to the main acoustic axes were observed in our initial patients, with the two most severe ones close to 45 degrees in the coronal plane. In this study, we investigated the reason for this oblique focus, reproduced results in a skull phantom, and demonstrated solutions for correcting the obliqueness using MR thermometry.

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