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Abstract #2334

Observing Diffusion-Weighted Imaging with Short Term Neuron Activity after Transcranial Focused-Ultrasound Induced Blood-Brain Barrier Opening in Small Animal

Po-Chun Chu 1 , Hong-Yu Chiu 2 , Wen-Yen Chai 1,3 , Yu-Cheng Pei 4,5 , You-Yin Chen 6 , and Hao-Li Liu 1

1 Department of Electrical Engineering, Chang-Gung University, Taoyuan, Taiwan, Taiwan, 2 Department of Life Sciences, National Yang-Ming University, Taipei, Taiwan, Taiwan, 3 Department of Diagnostic Radiology, hang-Gung University and Memorial Hospital, Taoyuan, Taiwan, Taiwan, 4 Department of Physical Medicine and Rehabilitation, Chang-Gung University and Memorial Hospital, Taoyuan, Taiwan, Taiwan, 5 School of Medicine, Chang Gung University, Taoyuan, Taiwan, Taiwan, 6 Department of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan, Taiwan

This study is to observe the effect and the relationship between the diffusion imaging (ADC mapping) and neuroactivity (SSEP waveform) after blood brain barrier opening by focus ultrasound with microbubbles. The result showed that the lower exposure make both ADC value and the SSEP waveform decrease but recovered in two days. However, the higher exposure make them both significant decrease and come back slower. We want to reveal more details need to be considered in the future neurophysiological, neuromodulation, or BBB issues.

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