Abstract #2334
Observing Diffusion-Weighted Imaging with Short Term Neuron Activity after Transcranial Focused-Ultrasound Induced Blood-Brain Barrier Opening in Small Animal
Po-Chun Chu 1 , Hong-Yu Chiu 2 , Wen-Yen Chai 1,3 , Yu-Cheng Pei 4,5 , You-Yin Chen 6 , and Hao-Li Liu 1
1
Department of Electrical Engineering,
Chang-Gung University, Taoyuan, Taiwan, Taiwan,
2
Department
of Life Sciences, National Yang-Ming University, Taipei,
Taiwan, Taiwan,
3
Department
of Diagnostic Radiology, hang-Gung University and
Memorial Hospital, Taoyuan, Taiwan, Taiwan,
4
Department
of Physical Medicine and Rehabilitation, Chang-Gung
University and Memorial Hospital, Taoyuan, Taiwan,
Taiwan,
5
School
of Medicine, Chang Gung University, Taoyuan, Taiwan,
Taiwan,
6
Department
of Biomedical Engineering, National Yang-Ming
University, Taipei, Taiwan, Taiwan
This study is to observe the effect and the relationship
between the diffusion imaging (ADC mapping) and
neuroactivity (SSEP waveform) after blood brain barrier
opening by focus ultrasound with microbubbles. The
result showed that the lower exposure make both ADC
value and the SSEP waveform decrease but recovered in
two days. However, the higher exposure make them both
significant decrease and come back slower. We want to
reveal more details need to be considered in the future
neurophysiological, neuromodulation, or BBB issues.
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