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Abstract #2338

Sympathetic Renal Denervation using MR guided Focused Ultrasound in a Porcine Model: a Feasibility Study

Allison Payne 1 , Matthias Koopmann 2 , Jill Shea 3 , Joshua de Bever 4 , Jose Reyes 2 , Emilee Minalga 5 , Robb Merrill 5 , J. Rock Hadley 5 , Dennis L. Parker 5 , and Nassir Marrouche 2

1 Radiology, University of Utah, Salt Lake City, UT, United States, 2 Cardiology, University of Utah, Utah, United States, 3 Surgery, University of Utah, Utah, United States, 4 Computer Science, University of Utah, Utah, United States, 5 Radiology, University of Utah, Utah, United States

Renal sympathetic denervation has been shown to be effective in reducing drug-resistant hypertension. Presented is a feasibility study performing renal denervation using MR guided focused ultrasound in a porcine model. Two animals were underwent unilateral renal denervation. A mean systolic and diastolic blood pressure change of -11.513.4 and -23.50.7 mmHg was observed. There were distinct differences in the histological appearance of the nerve bundles between the treated and non-treated sides and no indication of damage to either arterial wall demonstrating that MRgFUS can be effectively and safely used to perform renal denervation in a porcine model.

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