Abstract #2338
Sympathetic Renal Denervation using MR guided Focused Ultrasound in a Porcine Model: a Feasibility Study
Allison Payne 1 , Matthias Koopmann 2 , Jill Shea 3 , Joshua de Bever 4 , Jose Reyes 2 , Emilee Minalga 5 , Robb Merrill 5 , J. Rock Hadley 5 , Dennis L. Parker 5 , and Nassir Marrouche 2
1
Radiology, University of Utah, Salt Lake
City, UT, United States,
2
Cardiology,
University of Utah, Utah, United States,
3
Surgery,
University of Utah, Utah, United States,
4
Computer
Science, University of Utah, Utah, United States,
5
Radiology,
University of Utah, Utah, United States
Renal sympathetic denervation has been shown to be
effective in reducing drug-resistant hypertension.
Presented is a feasibility study performing renal
denervation using MR guided focused ultrasound in a
porcine model. Two animals were underwent unilateral
renal denervation. A mean systolic and diastolic blood
pressure change of -11.513.4 and -23.50.7 mmHg was
observed. There were distinct differences in the
histological appearance of the nerve bundles between the
treated and non-treated sides and no indication of
damage to either arterial wall demonstrating that MRgFUS
can be effectively and safely used to perform renal
denervation in a porcine model.
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