Real-time tracking of temperature, T1 and T2* during the onset of thermal damage in ex vivo and in vivo rabbit thigh muscle

A hybrid PRF/T1/T2* sequence is used to measure tissue temperature and the relaxation parameters T1 and T2* in real time during MR-guided focused ultrasound (MRgFUS) heating of in vivo and ex vivo rabbit thigh muscle. T1 and T2* are analyzed as functions of temperature and thermal dose to investigate whether they are sensitive to the various processes that occur during the onset and progression of tissue thermal damage.

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