Abstract #2354
Temperature mapping in Human Brown Adipose Tissue Using Fat-Water MRI with Explicit Fitting of Water Peak Location
Aliya Gifford 1,2 , Theodore F Towse 1,3 , Malcolm J Avison 1,4 , and E Brian Welch 1,5
1
Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States,
2
Chemical
and Physical Biology Program, Vanderbilt University,
Nashville, TN, United States,
3
Department
of Physical Medicine and Rehabilitation, Vanderbilt
University, Nashville, TN, United States,
4
Department
of Pharmacology, Vanderbilt University, Nashville, TN,
United States,
5
Department
of Radiology & Radiological Sciences, Vanderbilt
University, Nashville, TN, United States
This work aims to apply a novel fat-water MRI (FWRMI)-based
thermometry method to observations of both activated and
non-activated brown adipose tissue (BAT) in adult human
subjects, to demonstrate the methods ability to
distinguish between the two states of BAT. This FWMRI-based
thermometry method explicitly models the frequency shift
of the water peak due to temperature changes in regions
with both fat and water, such as BAT. FWRMI and PET-CT
scans were performed twice for each subject, after cold
and warm exposure. FWMRI mFFE scans were able to detect
temperature increase in BAT regions of subjects with
PET-confirmed BAT activation.
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