Abstract #2363
Evaluate Myocardial Function for Patient with Marfan Syndrome by Using Phase-Contrast Magnetic Resonance Imaging
Tzu-Yu Chou 1 , Hsin-Hui Chiu 2 , Wen-Yih Isaac Tseng 3 , Marius Menza 4 , Bernd Jung 4 , and Hsu-Hsia Peng 1
1
Department of Biomedical Engineering and
Environmental Sciences, Hsinchu, Taiwan,
2
Department
of Pediatrics, Taipei Medical University Hospital,
Taipei, Taiwan,
3
Center for Optoelectronic
Biomedicine, College of Medicine, National Taiwan
University, Taipei, Taiwan,
4
Medical
Physics, Department of Radiology, University Hospital
Freiburg, Freiburg, Germany
Marfan syndrome (MFS) is an inherent mutation of
encoding the fibrillin-1 protein. This protein is in
charge of forming microfibrils, which is a basic
material to build the elastic fibers. In this study, we
used dark-blood phase-contrast (PC) MRI to compute
myocardial wall motion velocity for MFS patients and
age-matched normal controls. MFS patients presented
higher systolic pVz values, shorter diastolic TTPz and
TTPr and achieved peak diastolic twist velocity in an
earlier phase. In conclusion, systolic pVz, diastolic
TTPz and TTPr, and twist velocity provide satisfied
information to diagnose myocardial function of MFS
patients.
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