Abstract #2374
Assessment of Longitudinal Changes in Contractile Function using DENSE in Patients with Myocardial Infarction
Christie McComb 1,2 , David Carrick 3 , Rosemary Woodward 2,4 , John McClure 2 , Aleksandra Radjenovic 2 , Colin Berry 2,3 , and John Foster 1,2
1
Clinical Physics, NHS Greater Glasgow &
Clyde, Glasgow, United Kingdom,
2
BHF
Glasgow Cardiovascular Research Centre, Glasgow, United
Kingdom,
3
Cardiology,
Golden Jubilee National Hospital, Glasgow, United
Kingdom,
4
MRI,
Golden Jubilee National Hospital, Glasgow, United
Kingdom
Myocardial infarction (MI) causes contractile
dysfunction in the affected tissue, which can be
assessed by using DENSE (Displacement ENcoding with
Stimulated Echoes) to quantify myocardial strain. Peak
circumferential strain and strain rate were measured in
50 patients within 7 days of MI, and 47 returned for a
follow-up scan after 6 months. Recovery of contractile
function was observed in infarcted myocardial segments,
and also in segments adjacent to infarction. Changes in
the mechanical properties of myocardium following MI are
complicated, but it appears that a reduction in infarct
size at follow-up is associated with a greater recovery
in contractile function.
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