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Abstract #2377

Probing Myocardial Blood Oxygenation Reserve of Canines with Controlled Hypercapnia Using T2-prepared BOLD MR

Hsin-Jung Yang 1 , Roya Yumul 1 , Richard Tang 1 , Ivan Cokic 1 , Michael Klein 2 , Avinash Kali 1 , Olivia Sobczyk 2 , Behzad Sharif 1 , Jun Tang 1 , Xiaoming Bi 3 , Sotirios Tsaftaris 4 , Diabao Li 1 , Antonio Conte 1 , Joseph Fisher 2 , and Rohan Dharmakumar 1

1 Cedars Sinai Medical Center, Los Angeles, California, United States, 2 University of Toronto, Toronto, ON, Canada, 3 Siemens Medical Solutions, IL, United States, 4 IMT Institute for Advanced Studies Lucca, Lucca, Italy

Our study evaluated the feasibility of a non-invasive stress-testing paradigm using a precisely targeted partial pressure of arterial CO2 (PaCO2) to induce myocardial hyperemia, and compared this response to intravenous adenosine using myocardial blood oxygenation dependent MRI. This is the first proof-of-concept study to demonstrate that precisely controlled hypercapnia can induce myocardial hyperemia equivalent to that induced by adenosine infusion under conditions of health and coronary narrowing. Coupled with BOLD MRI, this approach points to a new opportunity for a truly non-invasive cardiac stress test. Nevertheless, human studies are needed to examine the practical utility of this approach.

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