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Abstract #2389

Nonrigid 3D+t Image Registration for Temporal Averaging in Multiphase Coronary MR Angiography

Serena Y Yeung 1 , Nii Okai Addy 1 , R Reeve Ingle 1 , Bob S Hu 1,2 , and Dwight G Nishimura 1

1 Electrical Engineering, Stanford University, Stanford, CA, United States, 2 Palo Alto Medical Foundation, Palo Alto, CA, United States

High-resolution coronary magnetic resonance angiography (CMRA) enables finer depiction of coronary vessel detail, but at the same time introduces the challenge of compensating for a loss in SNR. In this work we demonstrate the ability of nonrigid 3D+t image registration to correct for interphase cardiac motion in multiphase acquisitions, thus enabling SNR gain through temporal averaging of the aligned images. 3D+t registration has two major advantages over standard 3D registration in this application: transformations are temporally as well as spatially smooth, and registration is performed globally without bias towards a specifically chosen reference image.

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