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Abstract #2418

DTI and Quantitative Histological Correlation of Diffuse Fibrosis in Failing Hearts

Osama Abdullah 1 , Stavros G Drakos 2 , Abdallah Kfoury 3 , Joseph Stehlik 3 , Craig H. Selzman 3 , Bruce B Reid 3 , Nikolaos A Diakos 2 , Kim Brunisholz 3 , Divya Ratan Verma 3 , Omar Wever-Pinzon 3 , Craig Myrick 4 , Dean Y Li 2 , and Edward W Hsu 1

1 Bioengineering, University of Utah, Salt Lake City, UT, United States, 2 Molecular Medicine Program, University of Utah, UT, United States, 3 UTAH Cardiac Transplant Program, UT, United States, 4 Intermountain Donor Services, UT, United States

Myocardial diffuse fibrosis has been linked to arrhythmias and sudden cardiac death. Although diffusion tensor imaging (DTI) is increasingly used to characterize cardiac diseases, quantitative correlation between DTI scalar metrics and diffuse fibrosis remains lacking. In this study, DTI parameters obtained on heart specimens from idiopathic dilated cardiomyopathy patients and normal donors were correlated to histological collagen content measurements. Results indicate that diffuse fibrosis is significantly correlated with water diffusivity, and inversely correlated with diffusion anisotropy. Computational analysis shows that the behaviors of the DTI parameters are well explained by compartmental exchange between myocardial and collagenous tissues.

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