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Abstract #2425

Instantaneous Signal Loss simulation (InSiL) An improved algorithm for myocardial T1 mapping using the MOLLI sequence

Jiaxin Shao 1 , Yutaka Natsuaki 2 , Bruce Spottiswoode 2 , Kim-Lien Nguyen 1,3 , and Peng Hu 1,4

1 Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, United States, 2 Siemens Healthcare USA, Inc., IL, United States, 3 Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA, United States, 4 Biomedical Physics Inter-Departmental Graduate Program, University of California, Los Angeles, CA, United States

We propose a new T1 mapping method, Instantaneous Signal Loss simulation (InSiL), for the MOLLI sequence. InSiL was evaluated against standard MOLLI using phantom study, and in 10 healthy volunteers at 1.5T. Phantom results show that the maximum absolute error by InSiL is less than 12ms, while that by MOLLI is more than 300ms for T1 values around 223ms-1641ms. InSiL reduced MOLLI T1 absolute error from 197ms to 4ms on average for T1>1000ms, HR≥80bpm. The native myocardial T1 values by InSiL were greater than that by MOLLI by 238.09.0ms (1166.023.1ms vs. 928.121.8ms) at an average heart rate of 63.711.2bpm.

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