Abstract #2433
Comparison of Cardiac Diffusion Tensor and Generalized Q-Sampling MRI
Eric P. Aliotta 1,2 , Marmar Vaseghi 3 , Kalyanam Shivkumar 3 , and Daniel B. Ennis 1,2
1
Biomedical Physics IDP, University of
California, Los Angeles, CA, United States,
2
Department
of Radiological Sciences, University of California, Los
Angeles, CA, United States,
3
Cardiac
Arrhythmia Center & EP Programs, University of
California, Los Angeles, CA, United States
Diffusion Tensor MRI (DT-MRI) is currently used to study
cardiac microstructure, but several limitations hinder
its ability to measure secondary and tertiary directions
of diffusion, which are important to our understanding
of cardiac myolaminar organization. Generalized
Q-sampling MRI (GQ-MRI) overcomes these limitations. We
compared primary, secondary, and tertiary directions of
diffusion between DT-MRI and GQ-MRI in ex vivo infarcted
porcine hearts and showed that the primary directions of
diffusion are in excellent agreement (7.1 median
difference), but that the secondary and tertiary
directions differ by 24.8 and 34.2. This disagreement
indicates that DT-MRI may not accurately characterize
myolaminar sheet orientation.
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