Abstract #2439
MICROSCOPIC VALIDATION DELAYED CONTRAST ENHANCED 3D INVERSION RECOVERY (IR) GRADIENT ECHO MRI IN BEATING AND NON-BEATING SWINE HEARTS
Maythem Saeed 1 , Robert Jablonowki 1 , Madhav Agrawal 1 , Steve W. Hetts 1 , and Mark W. Wilson 1
1
Radiology and Biomedical Imaging, University
of California, San Francisco, San Francisco, California,
United States
Contiguous, but not patchy, myocardial infarction has
been measured using 3D and 2D DE-MRI and validated using
histochemical and histopathological staining. The
purpose of this study was to: 1) measure patchy and
contiguous infarction size using delayed enhanced 3D
inversion recovery (IR) gradient echo (GRE) in beating
and non-beating swine hearts and 2) compare the 3D
measurements against 2D-IR GRE, histochemical and
histopathological staining. Myocardial infarction
measured on 3D MRI correlated well and in a good
agreement with microscopic data. This imaging sequence
has the potential to measure diffuse and large acute
myocardial infarction and has minimal motion artifacts.
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