Does phase contrast MRI provide the mean velocity of the spins within a voxel?

The underlying assumption with phase contrast (PC) is that all spins within a voxel move at the same velocity. This assumption is broken if the voxel is partially occupied by static spins or located at the viscous sublayer, or if the flow is complex or turbulent. We show that PC measurements may be accurately modeled as the mean velocity of all spins within each voxel. The proposed model, based on the spatial-velocity distribution of spins, could be useful towards bettering our understanding of partial volume effects in PC MRI velocimetry, especially if T ₁ contrast, in-flow enhancement, and noise are incorporated.

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