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Abstract #2483

Evaluation of mitral inflow in a rat model of aortic stenosis using phase contrast MRI

Kristine Skrdal 1,2 , Emil K. S. Espe 1,2 , Magnus Aronsen 1,2 , Lili Zhang 1,2 , and Ivar Sjaastad 1,2

1 Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Oslo, Norway, 2 KG Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Oslo, Norway

Assessment of diastolic dysfunction is important in basic research, involved in studying the mechanisms behind heart failure with preserved ejection fraction. However, more optimal methods are needed to study diastolic function in vivo in small animals. For the first time, phase contrast MRI (PC-MRI) has been extended to evaluate mitral inflow in a rat model. We found that PC-MRI can detect alterations in mitral flow, showing increased peak flow and deceleration rate of the mitral flow in response to disease. The results further advance the potential of PC-MRI as a complete method for evaluation of diastolic dysfunction in rodents.

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