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Abstract #2486

Analysis of Hemodynamic Parameters for Symptomatic Marfan Syndrome Patients by Phase-Contrast MRI

Hung-Hsuan Wang 1 , Hsin-Hui Chiu 2 , Shih-Han Hung 3 , Wen-Yih Isaac Tseng 4 , and Hsu-Hsia Peng 1

1 Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2 Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan, 3 Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, 4 Center for Optoelectronic Biomedicine, College of Medicine, National Taiwan University, Taipei, Taiwan

One of the most life-threatening complications for Marfan syndrome (MFS) patients is aortic dissection or rupture. Medical therapy to reduce the rate of aortic dilatation and risk of dissection, once MFS has been diagnosed, is now advocated. The purpose of this study is to analyze regional wall shear stress (WSS) and oscillatory shear index along the aorta of MFS patients with usage of noninvasive phase-contrast MRI. The values of WSS were significant lower in MFS patients. Regional distribution of WSSaxial displayed the chaotic flows in specific sites of the aorta, which may indicate potential sites with high risk of dissection.

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