Determination of Age-Related Regional Pulse Wave Velocity with 4D Flow MRI

Vascular stiffness is known to vary regionally along the aorta. This may be of particular interest with respect to focal diseases such as aneurysms. We implemented a semi-automated method to estimate regional PWV. The method was applied to estimate PWV in three equally sized segments in the descending aorta in 8 young and 8 older normal volunteer. The age-related differences in regional PWV observed agreed with previous studies and suggest that the PWV in the proximal and mid segments of the descending aorta increase more rapidly with age than the PWV in the distal descending aorta.

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