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Abstract #2540

Hemodynamic Abnormalities Reflected by Low Diastolic Wall Shear Stress and High OSI as Potential Determinants of Lower Abdominal Aortic Atherosclerosis

Masataka Sugiyama 1 , Yasuo Takehara 1 , Yang Wang 1 , Shuhei Yamashita 1 , Naoki Ooishi 1 , Marcus Alley 2 , Tetsuya Wakayama 3 , Atsushi Nozaki 3 , Hiroyuki Kabasawa 3 , and Harumi Sakahara 1

1 Radiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan, 2 Radiology, Stanford Unviersity School of Medicine, Palo Alto, CA, United States, 3 Applied Science Laboratory Asia Pacific, GE Healthcare Japan, Hino, Tokyo, Japan

26 consecutive patients who were examined both with 4D-Flow and CT were enrolled in the study. 4D-Flow was performed following 3D Gd-MRA. WSS and OSI of the aortic wall were calculated. Based on the CT findings, 10 atherosclerosis and 16 non-atherosclerosis in the lower abdominal aorta were subdivided. Multivariate logistic analysis showed that Diastolic WSS (p = 0.0224) and OSI (p = 0.0172) were independent determinant for the presence of atherosclerosis. Hemodynamic abnormalities reflected by low diastolic WSS and high OSI are considered to be potential determinants of lower abdominal atherosclerosis. 4D-Flow with an aid of flow analysis software can provide these hemodynamic parameters objectively.

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