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Abstract #2561

Absolute Temperature Measurement of QC Diffusion Phantoms via Low Bandwidth EPI

Thomas L. Chenevert 1 , Dariya I. Malyarenko 1 , Michael A. Boss 2 , and Scott D. Swanson 1

1 Radiology, University of Michigan, Ann Arbor, Michigan, United States, 2 Electromagnetics Division, National Institute of Standards and Technology (NIST), Boulder, Colorado, United States

Phantoms to assess diffusion measurement accuracy require knowledge of media temperature. Proton resonant frequency shift derived by phase difference, MRS, or echo interference pattern have been used to infer temperature. Thulium-based MR thermometry offers greater sensitivity, but requires wide frequency range. In this work, an EPI sequence is used to estimate the temperature-dependent spatial distance between two chemical shift targets. Sensitivity is improved by low bandwidth EPI and long-T2 chemical moieties. Spatial separation of two targets for temperature calibration is automatically determined using cross correlation. The proposed methodology is evaluated for absolute in-situ MR thermometry in a multi-component diffusion phantom.

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