Abstract #2568
Strategies for improved correction of EPI distortions in diffusion MRI with blip-up blip-down acquisitions
Mustafa Okan Irfanoglu 1,2 , Amritha Nayak 1,2 , Andrew Knutsen 3 , Pooja Modi 1 , Joelle Sarlls 3 , and Carlo Pierpaoli 1
1
NICHD, NIH, Bethesda, MD, United States,
2
CNRM,
USUHS, Bethesda, MD, United States,
3
NIH,
Bethesda, MD, United States
In this work, we propose a novel EPI distortion
correction scheme for diffusion weighted images with
reversed phase encoding gradient schemes. In addition to
describing the proposed method and comparing to existing
methodologies, we highlight several important factors
affecting these blip-up blip-down corrections and
analyze the effects of these factors. Our analysis
indicated that using additional anatomical image
information helps the registration under imperfect data
conditions and that using diffusion weighted image
contrast along with b=0 s/mm2 image significantly
improves anatomical accuracy, especially in tightly
packed regions such as the brain stem.
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